Electric Cell-substrate Impedance Sensing

ECIS® (Electric Cell-substrate Impedance Sensing) is a real-time, label-free, impedance-based method to study cell behaviors in tissue culture. These include monolayer barrier function, cell growth rates and viability, wound-healing migration and other behaviors directed by the cell’s cytoskeleton. The ECIS® approach has been applied to numerous investigations including measurements of endothelial monolayer permeability, in vitro toxicity testing as an alternative to animal testing, the invasive nature of cancer cells, and signal transduction involving GPCR’s for modern drug discovery.